In Vitro Comparison of the Anti-Proliferative Effects of Galenia africana on Human Skin Cell Lines

Malignant melanoma is the major cause of skin cancer-related deaths. Surgery in combination with radiotherapy, immunotherapy or chemotherapy used to eradicate cancer cells, however, this treatment option limited by tolerance surrounding healthy tissue. The extracts from Galenia africana have been shown possess anti-cancer flavonoid compounds and can be a safer cost-effective alternative treatment. study aimed compare anti-proliferative effects G. on human cells (HaCaT) malignant (A375). were exposed various concentrations extract at different times. In vitro assays employed determine cell viability cytotoxicity. Hoechst 33342 staining was performed observe nuclear changes, including apoptosis. significantly reduced A375 dose time-dependent manner, while having no effect HaCaT cells. displayed condensation, brightly stained nuclei fragmentation indicative This suggests clinical rationale for use as potential anti-melanoma agent offering efficacy low toxicity. provides new insights future work investigating utilization